Sedation choices and mortality: a well-defined tandem?

Mitochondrial Haplogroups and Well Defined Populations

A Comparison of Thematic Choices and Thematic Progression Patterns in the Research Articles of Well-established and Emerging Disciplines

Several studies have employed the theme-rheme construct to examine the generic profile of research articles (RAs). However, they have mostly focused on the subject matter and nature of disciplines, and other disciplinary characteristics as contextual factors which can impact the genre realization have not been considered in the discourse analysis research. This work, therefore, inve...

Targeted liquid chromatography tandem mass spectrometry to quantitate wheat gluten using well-defined reference proteins

Celiac disease (CD) is an inflammatory disorder of the upper small intestine caused by the ingestion of storage proteins (prolamins and glutelins) from wheat, barley, rye, and, in rare cases, oats. CD patients need to follow a gluten-free diet by consuming gluten-free products with gluten contents of less than 20 mg/kg. Currently, the recommended method for the quantitative determination of glu...

An asymptomatic well-defined brown coloured plaque on the eyebrow in a middle aged woman

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Reduction by well-defined objectives.

Examination of programmes of experimental work involving live animals indicates scope for worthwhile reduction in animal usage by identifying more clearly the objectives of the different stages of a programme. Having a defined first objective for new or transferred methodology as "to optimise the methods", rather than an exploratory "try it with a few animals and modify" approach, is more likel...